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  • Title: Microbial transformation of sclareolide.
    Author: Atta-ur-Rahman, Farooq A, Choudhary MI.
    Journal: J Nat Prod; 1997 Oct; 60(10):1038-40. PubMed ID: 9358647.
    Abstract:
    The microbial transformation of sclareolide (1) by Curvularia lunata afforded five oxidized metabolites identified as 3-ketosclareolide (2), 1 beta-hydroxysclareolide (3), 3 beta-hydroxysclareolide (4), 1 alpha,3 beta-dihydroxysclareolide (5), and 1 beta, 3 beta-dihydroxysclareolide (6). Fermentations of 1 with Aspergillus niger also produced metabolites 2-6. Metabolites 2-5 were obtained by fermention with Gibberella fujikuroii, while fermentation with Fusarium lini afforded metabolites 4 and 5.
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