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  • Title: Methotrexate use in psoriasis and psoriatic arthritis.
    Author: Cuellar ML, Espinoza LR.
    Journal: Rheum Dis Clin North Am; 1997 Nov; 23(4):797-809. PubMed ID: 9361156.
    Abstract:
    Methotrexate is an extremely effective drug in the treatment of psoriasis and psoriatic arthritis. In addition, it possesses a very high benefit-to-toxicity ratio compared with other therapies and immunosuppressive agents used in these disorders. Fortunately, most adverse events related to methotrexate are mild, but serious and life-threatening reactions, particularly liver toxicity, may occur. Careful monitoring is essential to prevent most undesirable side effects.
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