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  • Title: Clinical aspects of anti-inflammatory therapy in asthma.
    Author: Kumar A, Busse WW.
    Journal: Curr Opin Pulm Med; 1996 Jan; 2(1):40-7. PubMed ID: 9363114.
    Abstract:
    Anti-inflammatory therapy is now considered first-line treatment for mild to moderate asthma. Corticosteroids remain the most potent anti-inflammatory therapy available (although their mode of action is not clearly understood), and recent investigations suggest that earlier institution of anti-inflammatory therapy may be more beneficial than delayed therapy in newly diagnosed asthmatic patients. Inhaled corticosteroids have far fewer adverse effects than their oral counterparts; however, their risks must be carefully considered before use in mild asthma. These drugs can cause alterations in the hypothalamic-pituitary-adrenal axis, alter bone metabolism, and suppress growth in children. The potential long-term risk of these alterations remains the topic of much debate.
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