These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mechanisms of cycloheximide-induced apoptosis in liver cells.
    Author: Alessenko AV, Boikov PYa, Filippova GN, Khrenov AV, Loginov AS, Makarieva ED.
    Journal: FEBS Lett; 1997 Oct 13; 416(1):113-6. PubMed ID: 9369245.
    Abstract:
    Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide-induced apoptosis as an endogenous modulator of protein kinase C activity.
    [Abstract] [Full Text] [Related] [New Search]