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  • Title: Combined regional chemotherapy and radiation therapy in the treatment of epidermoid carcinoma in the oro-facial region.
    Author: Danko J, Satko I, Durkovský J.
    Journal: Neoplasma; 1979; 26(3):345-50. PubMed ID: 93709.
    Abstract:
    Followed treatment of oro-facial epidermoid carcinoma by combined chemo- and radiation therapy with eventual surgical intervention. Cytostatic drugs were applied intraarterially. After a monocytostatic treatment trial with Methotrexat (MTX), a combined cytostatic program was worked out utilizing two cytostatic drugs, viz. MTX and Bleomycin (BLM) in a cyclic alternation. Usefulness of chemotherapy and its inclusion into the treatment of epidermoid carcinoma in the oro-facial region was found justified principally in the case of combined therapy. However, the selected intraarterial mode of cytostatic administration is attended by certain drawbacks, mainly of a technical nature and is not suitable for routine application. For this reason, the authors have abandoned the i. a. mode of cytostatic administration in epidermoid oro-facial carcinoma and have adopted systemic application and this in combination with radiation, eventually surgical therapy with the utilization of chemotherapy.
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