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  • Title: Termination of obligate anoestrus and induction of fertile ovarian cycles in dogs by administration of purified pig LH.
    Author: Verstegen J, Onclin K, Silva L, Concannon P.
    Journal: J Reprod Fertil; 1997 Sep; 111(1):35-40. PubMed ID: 9370965.
    Abstract:
    The potential role of LH in the initiation of the follicular phase in dogs was investigated by treating anoestrous bitches with highly purified pig LH (n = 16) or saline (n = 8) three times a day for 7 days, beginning in either early anoestrus (days 94-116 of the cycle) or mid-anoestrus (days 124-145). Treatment with LH induced pro-oestrus within 7 days (n = 16), and oestrus (n = 12) and fertile ovulations (n = 7) at 16 + 3 days, while pro-oestrus in bitches treated with saline did not occur until 46-166 days after the start of treatment. Six of the seven ovulating bitches whelped normal litters. The bitches in which pro-oestrus but not oestrus occurred were all treated in early anoestrus. During treatment, plasma oestradiol in bitches treated with LH increased from 8 + 2 pg ml-1 to 20 + 5 pg ml-1 within 1 day, and reached higher peak values (45 + 7 pg ml-1) (P < 0.05) than those observed in saline-treated controls (9 + 3 ng ml-1). These results demonstrate that LH treatment alone can terminate anoestrus by inducing a normal follicular phase in dogs. The results also suggest that, in normal cyclic bitches, anoestrus is the result of insufficient LH secretion, and that spontaneous pro-oestrus could be the result of increased LH secretion in the presence of already adequate concentrations of FSH.
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