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  • Title: Influence of dobutamine on hemodynamics and coronary blood flow in patients with and without coronary artery disease.
    Author: Meyer SL, Curry GC, Donsky MS, Twieg DB, Parkey RW, Willerson JT.
    Journal: Am J Cardiol; 1976 Jul; 38(1):103-8. PubMed ID: 937182.
    Abstract:
    The influence of dobutamine on hemodynamics and coronary blood flow was studied in patients after routine cardiac catheterization. The data demonstrated that dobutamine is a powerful inotropic agent at a dose that has a relatively small influence on heart rate. In patients without coronary artery disease dobutamine greatly increased coronary arterial perfusion. In patients with severe coronary artery diseases dobutamine resulted in a much smaller increase in coronary perfusion, and the pattern of perfusion became more inhomogeneous. The results suggest that dobutamine has a potential inotropic value but raise concern about its influence on regional myocardial perfusion in patients with serious coronary artery disease.
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