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  • Title: Determination of urinary acylcarnitines by ESI-MS coupled with solid-phase microextraction (SPME).
    Author: Möder M, Löster H, Herzschuh R, Popp P.
    Journal: J Mass Spectrom; 1997 Nov; 32(11):1195-204. PubMed ID: 9373960.
    Abstract:
    The determination of selected short-, medium- and long-chain acylcarnitines by electrospray ionization mass spectrometry (ESI-MS) is discussed. The differences in fragmentation behaviour and ionization efficiency are described in dependence on collision induced dissociation (CID) conditions and mixture composition. A new method combination, solid-phase microextraction (SPME)-ESI-MS, is introduced to characterize acylcarnitines in body fluids. This method utilizes SPME for pre-concentration of acylcarnitines from complex biological samples and ESI-MS for a selective and sensitive detection. The method is presented by standard experiments determining of acylcarnitines in aqueous solutions and urine samples from patients with secondary carnitine deficiency syndromes or related disorders.
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