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  • Title: The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus.
    Author: Ferraro L, Antonelli T, O'Connor WT, Tanganelli S, Rambert F, Fuxe K.
    Journal: Neuroreport; 1997 Sep 08; 8(13):2883-7. PubMed ID: 9376524.
    Abstract:
    The antinarcoleptic drug modafinil [(diphenyl-methyl)-sulfinyl-2-acetamide; Modiodal] dose-dependently inhibits the activity of GABA neurons in the cerebral cortex and in the nucleus accumbens, as well as in sleep-related brain areas such as the medial preoptic area and the posterior hypothalamus. This study examined the effects of modafinil (30-300 mg/kg, i.p.) on dialysate glutamate and GABA levels in the ventromedial (VMT) and ventrolateral (VLT) thalamus and hippocampal formation (Hip) of the awake rat. The results show a maximal increase in glutamate release in these brain regions at the 100 mg/kg dose, associated with a lack of effect on GABA release. Thus modafinil may increase excitatory glutamatergic transmission in these regions, altering the balance between glutamate and GABA transmission.
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