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  • Title: Neuropathology of myelitis, myelopathy, and spinal infections in AIDS.
    Author: Budka H.
    Journal: Neuroimaging Clin N Am; 1997 Aug; 7(3):639-50. PubMed ID: 9376972.
    Abstract:
    In AIDS, pathology in the spinal contents usually follows that in the brain but is less frequent. Opportunistic infections are found in an average of 9.5% of spinal AIDS autopsies but in 54% of autopsies of the whole CNS. Necrotizing CMV radiculomyelitis is a rare (3.4% in spinal autopsies) but very characteristic opportunistic spinal lesion. The most prominent spinal cord disease in AIDS is vacuolar myelopathy, occurring in greatly differing frequencies according to different geographical areas, with a mean of about 22.5% in AIDS spinal cord autopsies. Its pathogenesis and clinicopathologic correlation need clarification; it appears to develop mainly in severely ill AIDS patients with significant viral load, advanced immunosuppression, and confounding metabolic imbalance.
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