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  • Title: New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase.
    Author: Bonnet B, Soullez D, Davioud-Charvet E, Landry V, Horvath D, Sergheraert C.
    Journal: Bioorg Med Chem; 1997 Jul; 5(7):1249-56. PubMed ID: 9377084.
    Abstract:
    Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 microM. Compound 32 (Ki = 0.4 microM) is the most potent TR inhibitor described so far.
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