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  • Title: Ganciclovir treatment of systemic cytomegalovirus in an immunocompetent host.
    Author: Leman JS, Toalson TW, Wlodaver CG.
    Journal: J Okla State Med Assoc; 1997; 90(7):367-9. PubMed ID: 9379249.
    Abstract:
    Cytomegalovirus (CMV) infects a significant number of otherwise healthy individuals. Although most cases are subclinical and therefore not diagnosed, some patients present with a mononucleosis-type illness. Ganciclovir, an agent effective against CMV, has primarily been studied for use in immunocompromised patients. No formal studies have been done in immunocompetent individuals. We report a case of an otherwise healthy adult female with severe heterophile negative infectious mononucleosis. Her symptoms included high fever, malaise, myalgias, cough, and abdominal pain. Work-up revealed an acute CMV infection. Intravenous ganciclovir was given with dramatic clinical and laboratory improvement.
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