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  • Title: [Hepatoid adenocarcinoma of the stomach. Case report and review of the literature].
    Author: Antonini C, Forgiarini O, Chiara A, Briani G, Sacchi G.
    Journal: Pathologica; 1997 Jun; 89(3):310-6. PubMed ID: 9380425.
    Abstract:
    Hepatoid adenocarcinoma of the stomach is an uncommon gastric tumor. A throughout search of the literature revealed only 86 cases: the first case was reported by Bourreille et al in 1970. We describe a patient with primary gastric adenocarcinoma with high serum alpha-fetoprotein (AFP) levels (7000 ng/ml). Histologically foci strongly resembling hepatocellular carcinoma with hyaline globules were noted. Immunoreactivity for alpha-fetoprotein (AFP), a1 antitrypsin and CEA also indicate hepatocellular differentiation. This case provides informations on the DNA content and Ki67 expression of this unusual and aggressive variant of gastric adenocarcinoma.
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