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  • Title: [Fosinorm in the treatment of essential hypertension with a metabolic syndrome].
    Author: Kobalava ZhD, Kotovskaia IuV, Moryleva ON, Drozdov VN, Ivleva AIa, Moiseev VS.
    Journal: Ter Arkh; 1997; 69(8):10-3. PubMed ID: 9381382.
    Abstract:
    The authors made an open-comparative trial of fosinopril (Fosinorm) efficacy and tolerability in 20 patients (9 males and 11 females) with stage II mild and moderate essential hypertension accompanied with disturbed glucose tolerance and dyslipidemia. Fosinorm was given in a dose 10 - 20 mg/day under 24-h monitoring of blood pressure. Diastolic pressure returned to normal in 19 (95%) patients, one patient showed a good hypotensive response. The mean 24-h fall in the systolic and diastolic pressure was significant and made up for systolic pressure 7.5% (9.2% and 9.2%), respectively. Fosinorm had a minimal effect on carbohydrate metabolism, total cholesterol, serum triglycerides. The conclusion is made that Fosinorm is a highly effective antihypertensive drug positively influencing 24-h profile of blood pressure in the absence of negative action on carbohydrate and lipid metabolism.
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