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  • Title: [Clinical efficacy of post-TUR prophylactic chemotherapy for superficial bladder cancer--the result of co-operative prospective randomized trial].
    Author: Takahashi Y, Kuriyama M, Yamada S, Fujimoto Y, Takeuchi T, Doi T, Sakai S, Isogai K, Kanematsu M, Hayashi H, Fujihiro S, Hasegawa Y, Ehara H, Maeda S, Itoh F, Kobayashi S, Horie M, Matsuda S, Takeda A, Tei KH, Kawada Y.
    Journal: Gan To Kagaku Ryoho; 1997 Sep; 24(12):1817-9. PubMed ID: 9382540.
    Abstract:
    We have performed a prospective randomized clinical trial of post-operative prophylactic therapy for superficial bladder cancer since October in 1991. The criteria were as follows; age < or = 80 y.o., Ta/T1, TCC G1/G2, without CIS lesion and resectable cancer by TUR. The therapeutic arm was divided into three as follows: arm A intracystic instillation with Epirubicin; arm B: oral administration with 5-FU; arm C: combination of arm A and arm B. The number of registered patients were 20 in arm A, 18 in arm B, and 18 in arm C. The patient characteristics in every group were not significantly different. The prophylactic efficacy of arm A was superior to that in the other two groups.
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