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  • Title: Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study.
    Author: Macchi G, Rossi G, Abbamondi AL, Giaccone G, Mancia D, Tagliavini F, Bugiani O.
    Journal: Brain Res; 1997 Oct 10; 771(1):154-8. PubMed ID: 9383019.
    Abstract:
    A morphometric investigation disclosed most thalamic nuclei severely degenerated in two patients with fatal familial insomnia. Associative and motor nuclei lost 90% neurons, and limbic-paralimbic, intralaminar and reticular nuclei lost 60%. These findings point to the disorganization of most thalamic circuits as a condition necessary for the sleep-wake rhythm being affected.
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