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  • Title: Glomerular atherosclerosis.
    Author: Moorhead JF, Brunton C, Varghese Z.
    Journal: Miner Electrolyte Metab; 1997; 23(3-6):287-90. PubMed ID: 9387135.
    Abstract:
    This paper suggests a two-hit model for lipoprotein-mediated progressive renal disease, in which postsecretory modification of low-density lipoprotein may favour the transformation of mesangial cells, monocytes and macrophages to glomerular foam cells. Proteinuria and lipiduria would mediate tubulointerstitial damage. Based on this, careful treatment with lipid-lowering agents, lipopheresis and antioxidants may ameliorate the progression of glomerular and tubulointerstitial pathology.
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