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  • Title: [Transplantation of human primary in-situ and invasive breast carcinoma in nude mice].
    Author: He L, Andersen JA.
    Journal: Zhonghua Zhong Liu Za Zhi; 1996 Sep; 18(5):321-3. PubMed ID: 9387265.
    Abstract:
    In order to establish nude mice model of early and advanced breast cancers, 15 in-situ breast carcinomas and 31 invasive breast carcinomoas were transplanted in 155 nude mice subcutaneously. A slow-release pellet of 17-beta estradiol was also implanted subcutaneously. During ten months of observation, the in-situ breast cancer tissue eventually did not grow. Light microscopy showed that the implants kept the structure of in-situ carcinoma without invasion. Of 31 invasive carcinomas, only one diagnosed pathologically as multifocal dedifferentiated ductal carcinoma grew well and was serially passaged. It was estrogen- and progesterone-receptor negative, p53 protein negative and c-erbB-2 protein positive. Its DNA ploidy was near tetraploidy.
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