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  • Title: A novel D-amino-acid-containing peptide isolated from Aplysia heart.
    Author: Morishita F, Nakanishi Y, Kaku S, Furukawa Y, Ohta S, Hirata T, Ohtani M, Fujisawa Y, Muneoka Y, Matsushima O.
    Journal: Biochem Biophys Res Commun; 1997 Nov 17; 240(2):354-8. PubMed ID: 9388481.
    Abstract:
    A novel cardio-excitatory peptide was purified from the hearts of Aplysia kurodai. The peptide was a tripeptide containing a D-amino acid residue in the second position, Asn-D-Trp-Phe-NH2 (NdWFamide). NdWFamide increased the amplitude of contractions of the perfused Aplysia heart with little effect on beating frequency, showing a threshold of approximately 10(-11) M. The peptide also potentiated spontaneous contractions of the anterior aorta. The synthetic peptide having L-Trp instead of D-Trp was about 1,000 times less potent than the native one. NdWFamide seems to play an important role in regulation of cardiac activity in Aplysia.
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