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  • Title: [Chemoradiation for malignant brain tumors].
    Author: Matsutani M.
    Journal: Gan To Kagaku Ryoho; 1997 Nov; 24(14):2042-8. PubMed ID: 9388512.
    Abstract:
    The author reviewed treatment results of chemoradiation therapy for malignant brain tumors. For astrocytic tumors, radiation therapy combined with radiosensitizing chemotherapeutic agents, mainly nitrosourea compounds (BCNU or ACNU), has been a standard treatment modality for a long time. The therapy is more effective for anaplastic astrocytoma than glioblastoma. The chemoradiation therapy is now applied for medulloblastoma; it prolonged 5-year survival up to 70%. Metastatic brain tumors are frequently treated by radiation therapy alone. When combined with cisplatin, radiation therapy shows a more excellent antitumor effect.
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