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  • Title: [Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer--results of a randomized trial].
    Author: Kaneta T, Takai Y, Nemoto K, Kakuto Y, Ogawa Y, Ariga H, Maruoka S, Ishibashi T, Hosoi Y, Yamada S.
    Journal: Gan To Kagaku Ryoho; 1997 Nov; 24(14):2099-104. PubMed ID: 9388519.
    Abstract:
    Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5 mg/m2) (arm B). For arm B group, CDDP was injected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy /30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response rate of 25.0%) was observed in arm A and 91.7% (complete response rate of 16.7%) in arm B, respectively. The survival rate at 1 year was 23.8% in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.
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