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  • Title: [Effect of microinjection of neurotensin into hypothalamic paraventricular nucleus on gastric acid secretion in rats].
    Author: Han XH, Chen JJ, Chen L.
    Journal: Sheng Li Xue Bao; 1996 Apr; 48(2):185-9. PubMed ID: 9389171.
    Abstract:
    Effects of microinjection of neurotensin (NT) into the hypothalamic paraventricular nucleus (PVN) on gastric acid secretion were investigated in urethane-anesthetized rats. The results were as follows: NT microinjection into PVN produced a dose-dependent decrease in gastric acid output (GAO); this inhibitory effect of NT was completely blocked by icv pretreatment with the alpha-adrenergic receptor antagonist phentolamine or after bilateral cervical vagotomy, suggesting that the effect may be related with activation of alpha-adrenergic receptors in the nucleus and mediated by vagal nerves.
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