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  • Title: Protein phylogenetic inference using maximum likelihood with a genetic algorithm.
    Author: Matsuda H.
    Journal: Pac Symp Biocomput; 1996; ():512-23. PubMed ID: 9390255.
    Abstract:
    This paper presents a method to construct phylogenetic trees from amino acid sequences. Our method uses a maximum likelihood approach which gives a confidence score for each possible alternative tree. Based on this approach, we developed a genetic algorithm for exploring the best score tree: randomly generated alternative trees are rearranged so that their scores are improved by utilizing crossover and mutation operators. In a test of our algorithm on a data set of EF-1 alpha sequences, we found that the performance of our algorithm is comparable to that of other tree-construction methods.
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