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  • Title: Differential effects of Asp-angiotensin II and Sar-angiotensin II on vascular and adrenal receptors in the dog.
    Author: Bravo EL, Khosla MC, Bumpus FM.
    Journal: Clin Sci Mol Med; 1976 Jul; 51(1):41-5. PubMed ID: 939065.
    Abstract:
    1. Adrenocorticotrophic hormone-suppressed, bilaterally nephrectomized male mongrel dogs (n = 12) were infused with Sar1-angiotensin II and Asp1-angiotensin II, the naturally occurring octapeptide. 2. Sar1-angiotensin II was found to be almost twice as potent as Asp1-angiotensin II in elevating blood pressure but its aldosterone-stimulating activity was not higher than that of the naturally occurring peptide. 3. A specific competitive antagonist of angiotensin II, Sar1-Ile8-angiotensin II, blocked the pressor but not the aldosterone-stimulating activity of Sar1-angiotensin II. 4. These results suggest functional differences in receptors for angiotensin II in vascular smooth muscle and in adrenal cortex.
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