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  • Title: Acute lymphoblastic leukemia with isolated adrenocorticotropic hormone deficiency.
    Author: Yamaguchi H, Nakamura H, Mamiya Y, Yamamoto Y, Tajika K, Sugihara H, Gomi S, Inokuchi K, Hasegawa S, Shibazaki T, Dan K, Wakabayashi I.
    Journal: Intern Med; 1997 Nov; 36(11):819-21. PubMed ID: 9392357.
    Abstract:
    A 57-year-old female was admitted to our hospital because of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). On admission, disturbance of consciousness and hyponatremia were recognized. The patient's endocrinological data showed low levels of adrenocorticotropic hormone (ACTH) (less than 5 pg/ml) and cortisol (5.9 microg/dl). Other anterior pituitary hormones were normal. Plasma ACTH and cortisol did not respond to the corticotropin releasing factor (CRF) test. A diagnosis of isolated ACTH deficiency was made. This is a rare case of isolated ACTH deficiency complicated with hematological malignancies.
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