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  • Title: Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo.
    Author: Lannutti BJ, Gately ST, Quevedo ME, Soff GA, Paller AS.
    Journal: Cancer Res; 1997 Dec 01; 57(23):5277-80. PubMed ID: 9393749.
    Abstract:
    Angiostatin inhibits angiogenesis and metastatic tumor growth; however, its usefulness in treating primary nonmetastasizing tumors is less well understood. We now report the effectiveness of human angiostatin administration in a mouse hemangioendothelioma model. Human angiostatin was administered to mice with s.c. hemangioendothelioma and associated disseminated intravascular coagulopathy (Kasabach-Merritt syndrome). Angiostatin significantly reduced tumor volume in comparison to nontreated controls, increased survival, and prevented the profound thrombocytopenia and anemia of Kasabach-Merritt syndrome. Apoptosis of tumor cells was induced by angiostatin, but tumor cell proliferation was not inhibited. These data suggest angiostatin as a novel treatment for nonmetastasizing vascular tumors and for Kasabach-Merritt syndrome.
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