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  • Title: The chromosomal signal for sex determination in Caenorhabditis elegans.
    Author: Meneely PM.
    Journal: Bioessays; 1997 Nov; 19(11):945-8. PubMed ID: 9394616.
    Abstract:
    In Caenorhabditis elegans, sex is determined by the number of X chromosomes which, in turn, determines the expression of the X-linked gene xol-1. Recent work has shown that xol-1 expression is controlled by least two distinct regulatory mechanisms, one transcriptional and another post-transcriptional. The transcriptional regulator is a repressor acting in XX embryos; although the specific gene has not been identified, the chromosome region has been defined. A previously defined regulator of xol-1, known as fox-1, maps to a different region of the X chromosome and works post-transcriptionally, consistent with the identification of the fox-1 gene product as a putative RNA binding protein.
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