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  • Title: Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine.
    Author: Fava M, Mulroy R, Alpert J, Nierenberg AA, Rosenbaum JF.
    Journal: Am J Psychiatry; 1997 Dec; 154(12):1760-2. PubMed ID: 9396960.
    Abstract:
    OBJECTIVE: The rate of adverse events following discontinuation of treatment with extended-release venlafaxine was compared with the rate associated with discontinuation of placebo administration. METHOD: The subjects were 20 outpatients with major depressive disorder who had participated in a multicenter, double-blind, placebo-controlled study of the efficacy of the new extended-release formulation of venlafaxine. RESULTS: During the 3 days after discontinuation of treatment with the study drug, seven (78%) of the nine venlafaxine-treated subjects and two (22%) of the nine placebo-treated patients reported the emergence of adverse events, a statistically significant difference. CONCLUSIONS: These results suggest that clinicians discontinuing venlafaxine treatment should consider tapering the medication dose gradually.
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