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  • Title: Localized unilateral periorbital edema induced by aspirin.
    Author: Price KS, Thomson DM.
    Journal: Ann Allergy Asthma Immunol; 1997 Nov; 79(5):420-2. PubMed ID: 9396974.
    Abstract:
    BACKGROUND: Aspirin intolerance manifested as bronchospasm or urticaria/angioedema has been observed since the beginning of this century. OBJECTIVE: To report a novel case of intolerance to aspirin ingestion. METHODS: Case report; routine skin testing; pulmonary function testing; aspirin challenge. RESULTS: A 30-year-old man with a history of left ocular trauma at the age of 10 noted a 3-year history of left periorbital angioedema after aspirin but not other nonsteroidal anti-inflammatory drugs. Incremental oral aspirin challenge resulted in this unilateral symptomatology at a dose of 673 mg. CONCLUSION: To the best of our knowledge, this is the first reported case of unilateral periorbital edema following aspirin ingestion.
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