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  • Title: Delayed hypersensitivity reaction to vancomycin.
    Author: Marik PE, Ferris N.
    Journal: Pharmacotherapy; 1997; 17(6):1341-4. PubMed ID: 9399623.
    Abstract:
    The use of vancomycin has increased dramatically in recent years with the emergence of methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci as important hospital pathogens. A patient receiving vancomycin 1.75 g intravenously as a single daily dose developed a syndrome characterized by high fever, erythema multiforme, eosinophilia, and presumed interstitial nephritis. This delayed hypersensitivity reaction resolved with discontinuation of the drug and treatment with methylprednisolone.
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