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  • Title: [The comparative study of LUMIWARD immunoassay system and CAP RAST system for determination of food allergy on infantile atopic dermatitis].
    Author: Miyoshi M, Sakurai T, Kodama S.
    Journal: Arerugi; 1997 Oct; 46(10):1036-43. PubMed ID: 9404091.
    Abstract:
    The reliability of assay methods was studied between LUMIWARD and CAP RAST due to the removal of some kinds of foods and/or challenge test. In the 45 infants with atopic dermatitis, egg, milk, flour, rice, and soybean were removed from foods and/or challenge test of those foods were carried out by every three months as possible. At the same time, the allergen-specific IgE antibodies were measured with LUMIWARD and CAP RAST. The negative concordance rate of LUMIWARD and CAP RAST. The negative concordance rate of LUMIWARD was elevated more than that of CAP RAST and the positive concordance rate of CAP RAST was elevated more than that of LUMIWARD. These results suggests that CAP RAST is useful for the determination of removal of foods, while LUMIWARD is useful for the determination of foods to challenge. The risk of overlooking the allergen exists, because the positive concordance concordance rates of LUMIWARD were low in the milk and flour. With developing age, the negative concordance rates decreased in CAP RAST, therefore unnecessary removal of foods may continue for a long time. The determination of low concentration with LUMIWARD was unreliable.
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