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  • Title: Actions of barium on rapidly inactivating potassium current in bullfrog sympathetic neurons.
    Author: Tokimasa T, Nishimura T.
    Journal: Neurosci Lett; 1997 Oct 24; 236(1):37-40. PubMed ID: 9404946.
    Abstract:
    Whole-cell/voltage-clamp recordings were made from dissociated bullfrog sympathetic neurons to examine the inhibitory actions of barium (0.01-3 mM) on a rapidly inactivating A-type potassium current (IA). The IC50 value was about 0.9 mM. Barium (1 mM) approximately halved the maximum amplitude of IA (approximately 1.7 nA near 0 mV) without significantly affecting a voltage for the 50%-activation (approximately -40 mV) and that for the 50%-inactivation (approximately -90 mV), nor did it affected the time course of IA. The results suggest that the barium block is independent of the kinetics of the A-channels in bullfrog sympathetic neurons.
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