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  • Title: Allergic nephropathy associated with norfloxacin and ciprofloxacin therapy. Report of two cases and review of the literature.
    Author: Hadimeri H, Almroth G, Cederbrant K, Eneström S, Hultman P, Lindell A.
    Journal: Scand J Urol Nephrol; 1997 Oct; 31(5):481-5. PubMed ID: 9406312.
    Abstract:
    Allergic nephropathy associated with quinolone antibiotics has been reported in an increasing number of cases. The mechanism might be a hypersensitivity reaction. Norfloxacin has been incriminated previously as a cause once only, with acute interstitial nephritis (AIN) as the histopathological finding. Ciprofloxacin-associated nephropathy has been reported in 28 cases, with AIN as the main histopathological finding. This report describes a second case of AIN associated with norfloxacin treatment and another ciprofloxacin-associated renal interstitial drug adverse reaction. Clinicians should be aware of quinolone-associated AIN, which is a rare but potentially dangerous renal complication.
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