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  • Title: Beta-endorphin, adrenocorticotropic hormone and cortisol secretion in abstinent alcoholics.
    Author: Marchesi C, Chiodera P, Ampollini P, Volpi R, Coiro V.
    Journal: Psychiatry Res; 1997 Oct 10; 72(3):187-94. PubMed ID: 9406908.
    Abstract:
    The circadian secretion of beta-endorphin, adrenocorticotropic hormone (ACTH), and cortisol was evaluated in 14 non-cirrhotic alcoholic men after 7 and 28 days of abstinence and in 12 sex- and age-matched normal subjects. A significant decrease in plasma levels of beta-endorphin, reduced ACTH levels, and increased cortisol levels were observed in samples taken at 08.00 h, 12.00 h, 18.00 h, and 23.00 h both after 7 and 28 days of abstinence. These data suggest the presence of a strong negative feedback on pro-opiomelanocortin synthesis by cortisol hypersecretion in abstinent alcoholics, which might be due to long-term stimulation of adrenal function by alcohol. The decreased plasma beta-endorphin levels might predispose to relapse in alcohol abuse.
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