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  • Title: Expression of sex hormone-binding globulin exon VII splicing variant messenger RNA in human uterine endometrial cancers.
    Author: Misao R, Nakanishi Y, Fujimoto J, Tamaya T.
    Journal: Cancer Res; 1997 Dec 15; 57(24):5579-83. PubMed ID: 9407970.
    Abstract:
    We have demonstrated the intracellular expression of sex hormone-binding globulin (SHBG) exon VII splicing variant mRNA in human uterine endometrial cancer using the reverse transcription-PCR-Southern blot and DNA sequencing analyses. Analysis of the missing base pairs proved that they corresponded to the entire exon VII, which is considered to encode a portion of the steroid-binding site, suggesting that the steroid-binding affinity of this variant might be different from that of the SHBG wild type. In uterine endometrial cancers, the wild-type mRNA levels significantly (P < 0.01) decreased, and the ratio of the SHBG variant to wild-type mRNA levels (P < 0.01) increased with the advance of histological dedifferentiation. These results suggest that dedifferentiation of endometrial cancers might induce a reduction in their estrogen-dependent properties via intracellular SHBG.
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