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  • Title: Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection.
    Author: Mizuno T, Momoi Y, Endo Y, Nishimura Y, Goto Y, Ohno K, Watari T, Tsujimoto H, Hasegawa A.
    Journal: J Vet Med Sci; 1997 Nov; 59(11):1049-51. PubMed ID: 9409524.
    Abstract:
    Feline immunodeficiency virus (FIV)-infected cells have been shown to undergo apoptosis by treatment with tumor necrosis factor alpha (TNF-alpha). This study detected a soluble factor which enhanced the apoptosis induced by TNF-alpha treatment. The sensitivity to TNF-alpha in the induction of apoptosis in a feline fibroblastoid cell line (CRFK) cells was significantly enhanced when the culture supernatant of FIV-infected CRFK cells or plasma samples from FIV-infected cats was added to the culture. These findings suggested that FIV infection induces production of a soluble factor which enhances CRFK cells sensitivity to TNF-alpha induction of apoptosis both in vitro and in vivo. This factor may contribute to the loss of lymphocytes in cats infected with FIV.
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