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  • Title: Expression cloning and characterization of a renal organic anion transporter from winter flounder.
    Author: Wolff NA, Werner A, Burkhardt S, Burckhardt G.
    Journal: FEBS Lett; 1997 Nov 17; 417(3):287-91. PubMed ID: 9409735.
    Abstract:
    The cDNA coding for a renal p-aminohippurate (PAH) transporter from winter flounder (Pseudopleuronectes americanus), designated fROAT, was cloned by functional expression in Xenopus laevis oocytes. fROAT is approximately 2.8 kbp in length and encodes a protein of 562 amino acids, related to the rat renal organic anion transporter ROAT1/OAT1 and the organic cation transporters OCT1 and OCT2. In oocytes, fROAT mediated probenecid-sensitive PAH uptake, with a Km for PAH of about 20 microM, and inhibited by external glutarate (GA) (1 mM). The functional characteristics suggest that fROAT is the basolateral PAH/dicarboxylate exchanger of the flounder kidney.
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