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  • Title: [Benign symmetrical lipomatosis: Madelung's disease].
    Author: Mevio E, Calabrò P, Redaelli GA, Perano D, Rosso R.
    Journal: Acta Otorhinolaryngol Ital; 1997 Feb; 17(1):64-7. PubMed ID: 9412157.
    Abstract:
    Multiple symmetrical lipomatosis, or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and in the upper body. The neoformations grow slowly and their initial consequence is purely esthetic. They can, however, lead to compression of the laryngeal-tracheal area and of the esophagus. This disease normally affects middle-aged males from the Mediterranean area with a history of alcohol abuse. Although most cases have been sporadic, a few authors have indicated that the disorder may be hereditary. It is thought that this pathology originates from an alteration in lipid metabolism. Surgical removal of the lipomatose mass is the treatment of choice even though there are frequently recurrences. A case is presented of a rare laryngeal localization of this disease and diagnosis and treatment are discussed.
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