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  • Title: Interaction of somatostatin and pentagastrin on lower oesophageal sphincter pressure (LESP) in man.
    Author: Rösch W, Lux G, Schittenhelm W, Demling L.
    Journal: Acta Hepatogastroenterol (Stuttg); 1976 Jun; 23(3):209-12. PubMed ID: 941623.
    Abstract:
    The effect of intravenous somatostatin on basal and gastrin-stimulated human lower esophageal sphincter pressure (LESP) was examined with the rapid pull-through technique. In a group of 7 healthy volunteers LESP was not influenced under basal conditions, but there was an augmented response to pulse-doses of pentagastrin (0.6 mug/kg) during infusion of somatostatin (250 mug/kg-h). The physiological importance of these findings still has to be evaluated.
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