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  • Title: The relationship of age, gender, handedness, and sidedness to the size of the corpus callosum.
    Author: Hopper KD, Patel S, Cann TS, Wilcox T, Schaeffer JM.
    Journal: Acad Radiol; 1994 Nov; 1(3):243-8. PubMed ID: 9419493.
    Abstract:
    OBJECTIVES: We correlated the area and size of the corpus callosum, as measured by MR imaging, with the individual's handedness, sidedness, age, and gender. MATERIALS AND METHODS: A total of 117 patients (59 male, 58 female) aged 15-75 years were selected for this study. This included 12 persons who were either left-handed or ambidextrous. Each patient was tested extensively to determine handedness and sidedness. Callosal areas and thickness were measured and correlated with brain size. RESULTS: The body of the corpus callosum decreases in size with age and is larger in right-handed persons. The cross-sectional areas of the genu, splenium, and corpus callosum, overall, do not vary significantly with respect to age, gender, sidedness, or handedness. CONCLUSIONS: The size of the corpus callosum consistently decreases with age. Otherwise, few statistical differences in callosal size relate to gender, sidedness, or handedness.
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