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  • Title: Magnetic resonance imaging of Long-Evans cinnamon rats as a new model of hepatocellular carcinoma.
    Author: Nakakoshi T, Kajiyama M, Fujita N, Jong-Hon K, Takeichi N, Miyasaka K.
    Journal: Acad Radiol; 1995 Jan; 2(1):50-2. PubMed ID: 9419524.
    Abstract:
    RATIONALE AND OBJECTIVES: Following hereditary hepatitis, Long-Evans Cinnamon (LEC) rats spontaneously develop hepatocellular carcinomas (HCC) histopathologically similar to human well-differentiated HCC. We demonstrated that LEC rats are an appropriate model of evaluating magnetic resonance (MR) imaging of well-differentiated liver tumors. METHODS: Six 23-25-month-old LEC rats were studied using liver MR imaging and histologic observation. RESULTS: Signal intensity of HCCs without cystic areas was normal or slightly high on T1-weighted images and slightly high on T2-weighted images. Histopathologically, most tumors resembled human highly or well-differentiated HCCs. CONCLUSION: The LEC rat is a good model of investigating MR imaging of well-differentiated HCC.
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