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  • Title: What clinicians need to know about antiviral drugs and viral resistance.
    Author: Hodinka RL.
    Journal: Infect Dis Clin North Am; 1997 Dec; 11(4):945-67. PubMed ID: 9421709.
    Abstract:
    The development of safe and effective antiviral therapies for the management of a variety of viral infections has expanded tremendously in recent years. Treatment is now possible for serious and potentially life-threatening infections with herpesviruses, respiratory viruses such as influenza A and respiratory syncytial virus, and the human immunodeficiency virus. The increased availability and use of antiviral drugs, however, has led to the emergence of drug-resistant viruses, especially in immunocompromised hosts. With this review, the major antiviral agents are presented with a description of the mechanisms of action, the evolution of drug resistance, and the need for in vitro antiviral susceptibility testing.
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