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  • Title: [Idiopathic and symptomatic hypereosinophilic syndromes (their comparative characteristics based on 14 cases)].
    Author: Khoroshko ND, Mokeeva RA, Turkina AG, Semenova EA, Pivnik AV.
    Journal: Ter Arkh; 1997; 69(7):26-33. PubMed ID: 9424754.
    Abstract:
    Clinical, hematological, cytogenetic and pathohistological findings in 14 patients with high eosinophilia allowed the authors to distinguish 2 groups of patients: with symptomatic (secondary) and idiopathic hypereosinophilic syndromes (6 and 8 patients, respectively). The latter was characterized by hepato- and splenomegaly, specific cardiac lesion (thromboplastic endocarditis), non-infectious fever, anemia and thrombocytopenia, marked hypercellularity of the bone marrow with inhibition of erythro- and megakaryocytopoiesis. Ph'-chromosome occurred in 2 out of 8 cases. Biopsy and autopsy histology in all cases of idiopathic hypereosinophilic syndrome were typical for myeloproliferative diseases. In symptomatic hypereosinophilic syndrome the above features were not registered.
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