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  • Title: Carrageenin-induced arthritis. I. The effect of intraarticular carrageenin on the chemical composition of articular cartilage.
    Author: Lowther DA, Gillard GC.
    Journal: Arthritis Rheum; 1976; 19(4):769-76. PubMed ID: 942506.
    Abstract:
    A single intraarticular injection of carrageenin into rabbit knee joints initiated a localized synovial inflammatory response. This response was accompanied by a 20% loss of proteoglycan from the articular cartilage within 24 hours and by a further 30-60% loss within 5-7 days. The chondrocytes replaced the lost proteoglycan within 42 days. More than two injections caused only a further small decrease in proteoglycan content; the cartilage was then unable to replace the lost proteoglycan. The absence of recovery coincided with the appearance of erosion of the cartilage surface.
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