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  • Title: K+ channels of expiratory neurones in the brain stem preparation of the newborn rat.
    Author: Jacquin TD, Descoins C, Champagnat J, Denavit-Saubie M.
    Journal: Neuroreport; 1997 Dec 01; 8(17):3673-8. PubMed ID: 9427349.
    Abstract:
    Single channel activity of expiratory neurones was studied in outside-out recordings. Expiratory neurones were identified in the ventrolateral region of the in vitro isolated brain stem-spinal cord preparation of newborn rats in cell-attached and whole-cell configurations by their pattern of firing related to phrenic motor output. Three potassium (K+) channels of 10, 30 and 70 pS exhibited steady-state activity during long voltage commands (up to 5 min) and could be found associated together in the same patches. The 30pS channel showed voltage dependency, being most active at small depolarizations. The 70 pS channel showed little activity with < 1% of openings per sample time and 1 mM tetraethylammonium (TEA) sensitivity. At similar concentrations, the discharge of the phrenic nerve was also altered, as shown by the increase of the respiratory frequency and a tonic discharge. The association of these K+ channel types on the same patches may be specific of respiratory neurones and could contribute to their bursting activity.
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