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  • Title: Toxicity of poly(rI).poly(rC) for interferon-treated cells. An ultrastructural evaluation.
    Author: Heremans H, Stewart WE, Billiau A, De Somer P.
    Journal: J Gen Virol; 1976 Jan; 30(1):131-5. PubMed ID: 942744.
    Abstract:
    The cytotoxic effect of poly(rI).poly(rC) for interferon-treated cells is preceded by discrete ultrastructural alterations in (1) the mitochondria: swelling of the cristae and increased density of their matrix, (2) the nucleus: disorganization of the structure, and (3) the endoplasmic reticulum: slight dilatation with disorganization and depletion of the filament bundles. Our results do not allow us to conclude whether any of these alterations is a primary effect of the treatment. Possibly they are secondary to some, as yet unknown, functional defect, and only reflect incipient cell death.
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