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  • Title: Permeability of human chorion laeve to diazepam and meperidine.
    Author: Seeds AE, Stolee A, Eichhorst BC.
    Journal: Obstet Gynecol; 1976 Jan; 47(1):28-30. PubMed ID: 942777.
    Abstract:
    In vitro placental permeability to diazepam (Valium) and meperidine (Demerol) in excess of that measured for antipyrine, suggest that these compounds will diffuse across placental tissue in vivo at a maximal or perfusion-limited rate. Such findings correspond to the high fetal blood levels reported for these substances following maternal administration and indicate that these lipid-soluble analgesics cross this tissue by transcellular as well as extracellular pathways.
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