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  • Title: Flow cytometric DNA analysis of pediatric intracranial ependymomas.
    Author: Kotylo PK, Robertson PB, Fineberg NS, Azzarelli B, Jakacki R.
    Journal: Arch Pathol Lab Med; 1997 Dec; 121(12):1255-8. PubMed ID: 9431314.
    Abstract:
    OBJECTIVE: To examine the clinicopathologic features and perform flow cytometric DNA analysis of pediatric intracranial ependymomas to determine whether any of these parameters were predictors of clinical outcome. METHODS: Flow cytometric DNA analysis was performed on 17 paraffin-embedded tumors from patients aged 7 months to 16 years. RESULTS: Seven cases were aneuploid, while the remaining 10 were diploid. Proliferative fractions varied from 1% to 17%. CONCLUSIONS: No correlation between histologic features such as mitotic activity, cellularity, pleomorphism, vascular proliferation, and length of survival was observed. However, the presence of a diploid DNA stemline, elevated proliferative fraction, or young age were associated with a poor clinical outcome and shortened survival times (P < 0.05). Additional studies of larger patient groups with extended follow-up are necessary to confirm these findings.
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