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  • Title: [Neuroendocrine tumors and liver transplantation: review based on a case report].
    Author: Inturri P, Galligioni A, Halmos O, Burra P, Graziotto A, Rossaro L.
    Journal: Orv Hetil; 1997 Dec 07; 138(49):3121-4. PubMed ID: 9432656.
    Abstract:
    A case of orthotopic liver transplantation (OLT) for secondary Neuroendocrine Tumor (NET), whose primary site was not detected at the time of surgery, is reported. The primary pancreatic lesion was found 20 months later in association with recurrence of neoplasm in the graft and with a paraneoplastic syndrome peculiar of glucagonoma. The patient started octreoide therapy with a decrease of the glucagone level but without reduction of the tumor size, nor disappearance of the clinical syndrome. A few months later the primary lesion was surgically removed, but her general condition deteriorated and the patient died waiting for liver retransplantation. A discussion about the management and the diagnostic tools for preoperative staging of these neoplasms and their ability to identify the primitive and secondary location of neuroendocrine tumors is presented.
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