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  • Title: Factors influencing the identification of major genes in a complex disease genome scan.
    Author: Yang H, Wang Y, Goldstein DR, Li Z, Vora H, Cantor RM.
    Journal: Genet Epidemiol; 1997; 14(6):933-8. PubMed ID: 9433603.
    Abstract:
    A two-stage linkage strategy was employed to identify major genes for a simulated complex disease via a genome scan. The importance of several approaches for improving the ability to locate major genes has been illustrated. These approaches are: adjusting for covariates, ascertaining through multiple affected family members, increasing the sample size, and using multipoint linkage analysis.
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